I 81 $south, I 59 $south
1,087.1 mi16 hours 27 mins
| Head south on 14th Street Northwest (US 1 N) | 300 feet | |
| Continue onto 14th Street Southwest (US 1 N) | 700 feet | |
| Turn right onto Independence Avenue Southwest | 1.1 mi | |
| Continue onto Ohio Drive Southwest | 0.2 mi | |
| Keep right onto Potomac Freeway | 400 feet | |
| Take the ramp towards I 66 West: E Street | 200 feet | |
| Keep right towards I 66 West | 0.9 mi | |
| Continue onto Custis Memorial Parkway (I 66 W) | 74.4 mi | |
| Keep left towards I 81 South: Roanoke | 0.6 mi | |
| Merge right towards I 81 South: Roanoke | 375.9 mi | |
| Merge left onto I 40 | 52.7 mi | |
| Keep left towards I 75 South: Chattanooga | 10.2 mi | |
| Keep right onto I 75 S | 800 feet | |
| Keep left onto I 75 S | 72.9 mi | |
| Take the ramp towards I 24 West: Chattanooga | 0.6 mi | |
| Continue towards Chattanooga | 16.7 mi | |
| Take exit 167 on the left towards I 59 South: Birmingham | 0.8 mi | |
| Continue onto I 59 S | 123.2 mi | |
| Take exit 137 on the left towards I-459 South: Tuscaloosa | 0.5 mi | |
| Continue onto John M. Harbert III Freeway (I 459 S) | 22.0 mi | |
| Continue onto I-459 S | 2.0 mi | |
| Continue onto John M. Harbert III Freeway (I 459 S) | 8.6 mi | |
| Keep left towards I 20 West: Tuscaloosa | 1.2 mi | |
| Merge left onto I 20 | 126.9 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 106.4 mi | |
| Keep left at the fork | 1.0 mi | |
| Merge right onto I 10 | 32.1 mi | |
| Take the ramp towards Superdome | 800 feet | |
| Keep right onto Cleveland Avenue | 300 feet | |
| Turn right onto South Claiborne Avenue | 600 feet | |
| Turn left onto Tulane Avenue | 0.2 mi | |
| Turn right onto Lasalle Street | 700 feet | |
| You have arrived at your destination |
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Washington, District of Columbia - New Orleans, Louisiana