I 40, I 75 $north
387.7 mi6 hours 15 mins
| Head north on Greenwood Highway (US 221) | 4.6 mi | |
| Continue onto Greenwood Road (US 221) | 5.6 mi | |
| Continue onto South Harper Street (US 221) | 2.2 mi | |
| Continue onto Lucas Avenue (US 221) | 0.7 mi | |
| Turn right onto Yarborough Mill Road (SC 49) | 1.8 mi | |
| Continue onto State Highway 49 (SC 49) | 6.5 mi | |
| Continue onto Union Highway (SC 49) | 1.0 mi | |
| Take the ramp on the left | 900 feet | |
| Merge left onto I 26 W | 83.5 mi | |
| Take the ramp on the left towards I 40 West: Canton | 110.1 mi | |
| Take the ramp towards I 275 North: Lexington | 0.4 mi | |
| Continue onto I 275 N | 3.0 mi | |
| Continue onto I 75 N | 163.0 mi | |
| Take the ramp towards US 60: Lexington | 0.4 mi | |
| Turn left onto Winchester Road (US 60) | 3.5 mi | |
| Turn left onto Midland Avenue (US 60) | 0.5 mi | |
| Continue straight to stay on Midland Avenue | 200 feet | |
| Make a slight right onto East Main Street (US 25) | 0.7 mi | |
| Turn left onto South Broadway (US 27) | 200 feet | |
| You have arrived at your destination |
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Waterloo, South Carolina - Lexington, Kentucky