I 70, I 74 $east
380.9 mi6 hours 5 mins
| Head south on Blumhoff Avenue | 200 feet | |
| Turn left onto West Allen Street | 200 feet | |
| Turn right onto North Linn Avenue | 100 feet | |
| Turn right onto West Main Street | 400 feet | |
| Turn left onto South Church Street | 0.3 mi | |
| Enter the roundabout and take the 2nd exit onto South Church Street (MO Z) | 100 feet | |
| Exit the roundabout onto South Church Street (MO Z) | 400 feet | |
| Take the ramp on the left | 900 feet | |
| Merge left onto I 70 E | 13.7 mi | |
| Keep right towards MO 370 East | 13.0 mi | |
| Continue onto I 270 E | 27.7 mi | |
| Merge right towards I 70 East: Indianapolis | 82.7 mi | |
| Keep right towards I 70 East: Indianapolis | 131.9 mi | |
| Take the ramp towards Sam Jones Expressway | 0.6 mi | |
| Merge left onto Sam Jones Expressway | 1.2 mi | |
| Continue onto West Raymond Street | 7.7 mi | |
| Make a slight right onto Southeastern Avenue | 0.8 mi | |
| Continue onto [Southeastern Avenue Connector] | 1.0 mi | |
| Continue onto I 74 E | 84.2 mi | |
| Merge right onto Cincinnati By-Pass (I 74 E) | 2.7 mi | |
| Keep right towards I 75 East: Cincinnati | 9.6 mi | |
| Continue onto I 74 E | 0.4 mi | |
| Keep right towards I 75 South: Lexington | 0.5 mi | |
| Merge left onto Mill Creek Expressway (I 75 S) | 0.3 mi | |
| Take exit 3 towards US 27 South: Hopple Street | 0.3 mi | |
| Turn left to stay on Hopple Street (US 27 S) | 200 feet | |
| Continue onto Hopple Street Viaduct (US 52 S) | 900 feet | |
| Continue onto Martin Luther King Drive West | 0.8 mi | |
| Make a slight right | 100 feet | |
| Turn right onto Clifton Avenue | 0.5 mi | |
| Turn left onto West McMillan Avenue | 0.3 mi | |
| Turn right onto Ohio Avenue | 100 feet | |
| You have arrived at your destination, on the left |
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Wentzville, Missouri - Cincinnati, Ohio