I 71 $south; I 75 $south, I 71 $south
144.2 mi2 hours 26 mins
| Head southeast on Liberty Avenue (US 27) | 100 feet | |
| Continue onto Main Street (US 27) | 0.3 mi | |
| Continue onto College Corner Pike (US 27) | 4.9 mi | |
| Continue slightly left onto West Church Street (US 27) | 0.2 mi | |
| Turn right onto North College Avenue (US 27) | 400 feet | |
| Turn left onto West High Street (US 27) | 900 feet | |
| Turn right onto South Main Street (SR 732) | 0.7 mi | |
| Turn left onto East Chestnut Street | 0.6 mi | |
| Turn right onto Oxford Millville Road (US 27) | 4.0 mi | |
| Continue onto Millville Oxford Road (US 27) | 4.9 mi | |
| Turn right onto Walnut Street (US 27) | 0.3 mi | |
| Continue onto Millville Ross Road (US 27) | 10.2 mi | |
| Take the ramp towards I 275 West: Indianapolis | 0.3 mi | |
| Merge left onto Cincinnati By-Pass (I 275 W) | 4.8 mi | |
| Take exit 28 on the left towards I 74 East: Cincinnati | 0.4 mi | |
| Merge left towards I 75 East: Cincinnati | 9.1 mi | |
| Continue onto I 74 E | 0.4 mi | |
| Keep right towards I 75 South: Lexington | 0.5 mi | |
| Merge left onto Mill Creek Expressway (I 75 S) | 4.0 mi | |
| Continue onto Brent Spence Bridge (I 71 S) | 18.8 mi | |
| Take the ramp towards I 71 South: Louisville | 76.8 mi | |
| Take the ramp towards I 64 West: Saint Louis | 0.5 mi | |
| Merge left onto I 64 W | 1.5 mi | |
| Take the ramp towards 9th Street | 0.5 mi | |
| Keep right at the fork | 300 feet | |
| Go straight onto West Jefferson Street | 300 feet | |
| You have arrived at your destination |
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West College Corner, Indiana - Louisville, Kentucky