I 80 $south; US 220 $south, I 80
128.6 mi2 hours 2 mins
| Head northeast on West 3rd Street | 100 feet | |
| Turn right onto Market Street | 800 feet | |
| Take the ramp | 200 feet | |
| Continue towards I 180 West: Lock Haven | 0.2 mi | |
| Merge left onto Susquehanna Beltway (I 180 W) | 1.6 mi | |
| Keep left towards US 220 South: Lock Haven | 12.1 mi | |
| Continue onto Appalachian Thruway (US 220 S) | 15.9 mi | |
| Take exit 107 towards PA 477: Salona | 0.2 mi | |
| Turn right onto PA 477 | 400 feet | |
| Turn left onto Fernberg Road (PA 64) | 0.4 mi | |
| Continue onto Nittany Valley Drive (PA 64) | 4.0 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 80 S | 11.8 mi | |
| Continue onto I 80 | 79.0 mi | |
| Take the ramp towards PA 28: Hazen | 1,000 feet | |
| Turn left onto PA 28 S | 1.5 mi | |
| Continue onto US 322 | 0.9 mi | |
| Turn right onto North White Street | 400 feet | |
| You have arrived at your destination |
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Williamsport, Pennsylvania - Brookville, Pennsylvania