I 80, William Penn Highway
191.5 mi3 hours 7 mins
| Head northeast on Market Street | 100 feet | |
| Turn left onto West Front Street | 0.5 mi | |
| Keep left onto West Federal Street | 800 feet | |
| Continue onto Martin Luther King Junior Boulevard | 0.2 mi | |
| Turn left to stay on Martin Luther King Junior Boulevard (SR 289) | 1.2 mi | |
| Take the ramp | 0.4 mi | |
| Merge right onto SR 711 N | 1.5 mi | |
| Take the ramp towards I 80 East: New York | 0.6 mi | |
| Merge right onto I 80 | 130.7 mi | |
| Take the ramp towards PA 970 to US 322: Woodland | 0.3 mi | |
| Go straight onto Shawville Highway (PA 970) | 1.4 mi | |
| Turn left onto Woodland Bigler Highway (US 322) | 2.8 mi | |
| Continue onto Philipsburg Bigler Highway (US 322) | 7.1 mi | |
| Continue onto North Front Street (US 322) | 0.3 mi | |
| Continue onto North Centre Street (US 322) | 800 feet | |
| Turn left onto Railroad Street (US 322) | 1.0 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.5 mi | |
| Continue onto Upper Flat Rock Road (US 322) | 1.6 mi | |
| Continue onto Flat Rock Road (US 322) | 1.5 mi | |
| Continue onto 28th Division Highway (US 322 E) | 0.3 mi | |
| Take the ramp towards US 220 Alternate: Port Matilda | 0.2 mi | |
| Continue onto North High Street | 0.6 mi | |
| Take the ramp on the right towards I 99 South: Altoona | 0.4 mi | |
| Merge left onto I 99 S | 12.9 mi | |
| Take the ramp towards PA 453: Tyrone | 0.4 mi | |
| Turn left onto Birmingham Pike (PA 453) | 9.0 mi | |
| Turn left onto William Penn Highway (US 22 E) | 9.7 mi | |
| You have arrived at your destination |
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Youngstown, Ohio - Smithfield, Pennsylvania