I 81 $south, I 77 $south
651.3 mi10 hours 10 mins
| Head north on North 6th Street (PA 145 N) | 0.8 mi | |
| Turn left onto West Washington Street (PA 145 N) | 600 feet | |
| Turn right onto North 7th Street (PA 145) | 0.3 mi | |
| Continue onto MacArthur Road (PA 145) | 0.7 mi | |
| Take the ramp towards US 22 West: Harrisburg | 0.2 mi | |
| Merge left onto Lehigh Valley Thruway (US 22 W) | 6.4 mi | |
| Merge left onto William Penn Highway (I 78 W) | 43.1 mi | |
| Continue onto 78th Division Highway (I 78 W) | 7.6 mi | |
| Continue towards I 81 South: Harrisburg | 0.7 mi | |
| Merge left onto I 81 S | 369.1 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue onto I 77 S | 100.6 mi | |
| Keep right onto I 77 S | 16.7 mi | |
| Take the ramp towards I 485 OUTER: Pineville | 0.3 mi | |
| Keep right at the fork | 0.9 mi | |
| Merge left onto I 485 | 10.3 mi | |
| Take the ramp towards I 85: Spartanburg | 0.4 mi | |
| Keep right towards I 85 South: Spartanburg | 0.9 mi | |
| Merge left onto I 85 S | 82.2 mi | |
| Take the ramp towards Pelham Road | 0.4 mi | |
| Keep right towards Pelham Road | 200 feet | |
| Go straight onto Pelham Road | 4.4 mi | |
| Turn left onto Haywood Road | 0.2 mi | |
| Take the ramp on the right | 0.2 mi | |
| Merge left onto I 385 N | 2.9 mi | |
| Continue onto East North Street | 0.2 mi | |
| Continue onto Beattie Place (SC 183) | 0.2 mi | |
| Turn left onto North Church Street (US 29) | 0.2 mi | |
| Turn right onto East Washington Street | 0.2 mi | |
| You have arrived at your destination |
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Allentown, Pennsylvania - Greenville, South Carolina